Effect of Bilirubin UDP Glucuronosyltransferase 1 Gene TATA Box Genotypes on Serum Bilirubin Concentrations in Chronic Liver Injuries
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منابع مشابه
Effect of bilirubin UDP glucuronosyltransferase 1 gene TATA box genotypes on serum bilirubin concentrations in chronic liver injuries.
TATA box abnormality in the promoter region of the bilirubin UDP glucuronosyltransferase 1 gene has been reported to cause Gilbert's syndrome in white subjects. It has also been reported that the majority of Japanese patients with Gilbert's syndrome are heterozygous for Gly71Arg in the coding region of this gene. On the other hand, some patients with chronic hepatitis often show signs of unexpe...
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drome) to Serum Bilirubin Concentrations in the Italian Population, Maria Luisa Biondi, Olivia Turri, Dario Dilillo, Giorgio Stival, and Emma Guagnellini ( Laboratorio di Chimica Clinica e Microbiologia, Azienda Ospedaliera San Paolo, Via di Rudinı̀ 8, 20142 Milan, Italy; 2 Clinica Pediatrica, Azienda Ospedaliera San Paolo, Università di Milano, Via di Rudinı̀ 8, 20142 Milan, Italy; * author for ...
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We report the isolation and characterization of two human liver cDNA clones, HUG-Br1 and HUG-Br2; each encodes a UDP-glucuronosyltransferase enzyme which glucuronidates bilirubin IX alpha to form both the IX alpha C8 and IX alpha C12 monoconjugates and a diconjugate. HUG-Br1 cDNA (2351 base pairs) and HUG-Br2 cDNA (2368 base pairs) encode proteins with 533 and 534 amino acid residues, respectiv...
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Hepatic biotransformation of bilirubin to the hydrophilic species bilirubin mono- (BMG) and diglucuronide (BDG) by microsomal bilirubin UDP-glucuronosyl-transferase (GT) is a prerequisite for its physiologic excretion into bile. The reaction mechanism of bilirubin-GT and the access of bilirubin and BMG (the intermediate substrate) to the active site of bilirubin-GT are undefined. Highly purifie...
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Thirty-seven healthy volunteers, 19 of whom had consistently elevated total serum bilirubin (TSB) concentrations, took part in an open, randomised cross-over study to determine the effect of fasting on TSB concentrations. The study comprised of two treatments. During one treatment period volunteers ate a standard supper but fasted for 24 h thereafter. During the other treatment period volunteer...
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ژورنال
عنوان ژورنال: Hepatology
سال: 2000
ISSN: 0270-9139,1527-3350
DOI: 10.1053/jhep.2000.16331